Attenuated measles virus as a vaccine vector

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Mucosal DNA vaccine immunization against measles with a highly attenuated Shigella flexneri vector.

An intranasal vaccine vector would elicit protective immunity at the respiratory mucosa, the portal of entry and the primary site for replication for measles virus (MV) and other respiratory viruses. In a murine model of pulmonary Shigella, we demonstrate here that a candidate-attenuated Shigella vaccine vector is safely tolerated in IFN-gamma deficient mice at an inoculum that is 1 million-fol...

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A highly attenuated measles virus vaccine strain encodes a fully functional C protein.

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ژورنال

عنوان ژورنال: Vaccine

سال: 2007

ISSN: 0264-410X

DOI: 10.1016/j.vaccine.2007.01.064